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Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population

Suzanne A Al-Bustan1, Fatma G Ismael1, Ahmad Al-Serri2

  • 1Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait.

Disease Markers
|January 25, 2018
PubMed

Insights

The APOB rs11279109 DD genotype is linked to a higher risk of coronary heart disease (CHD) in Kuwaitis. This genetic marker may aid in early diagnosis and prevention strategies for CHD.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology

Background:

  • Coronary heart disease (CHD) is a major cause of mortality in Kuwait.
  • Investigating genetic factors contributing to CHD risk in the Kuwaiti population.

Purpose of the Study:

  • To determine the association between the APOB rs11279109 polymorphism and CHD in Kuwaiti individuals.
  • To explore the potential of APOB rs11279109 as a genetic marker for CHD risk.

Main Methods:

  • A case-control study involving 734 Kuwaiti participants.
  • Genotyping of the APOB rs11279109 polymorphism using direct amplification.
  • Statistical analysis with genetic modeling to assess the association with CHD.

Main Results:

  • A significant association was found between the rs11279109 DD genotype and CHD (P < 0.001).
  • The DD genotype showed an odds ratio of 2.43 (CI: 1.34-4.41) for CHD.
  • A codominant model indicated a 2.69 increased risk for the DD genotype (P = 0.009), independent of other risk factors.

Conclusions:

  • The APOB rs11279109 DD genotype may be an indicator of increased CHD risk in Kuwaitis.
  • This genotype might be involved in molecular mechanisms of increased LDL oxidation and atherosclerosis.
  • Highlights the importance of identifying ethnic-specific genetic markers for improved CHD prognosis, diagnosis, and prevention.
Abstract

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