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Published on: April 1, 2019
Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis
Osamu Nunobiki1, Daisuke Sano2, Sakae Hata2
1Department of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan. o-nunobiki@kobe-tokiwa.ac.jp.
Abstract:
To investigate the clinical significance of human wings apart-like (hWAPL) genetic polymorphisms in cervical carcinogenesis. hWAPL polymorphisms and human papillomavirus (HPV) types were examined in 175 cervical smears of exfoliated cervical cell samples using a real-time polymerase chain reaction system. A significant difference was detected in the frequency of the CC genotype between the HPV(+) low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) groups [Odds ratio 0.21, 95% confidence interval (CI) 0.0723-0.61; P = 0.0029]. A significant difference was noted in the frequency of the CC genotype between the high-risk HPV-positive LSIL and HSIL groups (odds ratio 0.2955, 95% CI 0.0893-0.9771; P = 0.0414). The CC genotype of hWAPL gene promoter polymorphism may be associated with cervical carcinogenesis.
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