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Related Concept Videos

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Related Experiment Video

Updated: Feb 15, 2026

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
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Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

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Metabolomics in Immunology Research.

Bart Everts1

  • 1Department of Parasitology, Leiden University Medical Center (LUMC), Leiden, The Netherlands. b.everts@lumc.nl.

Methods in Molecular Biology (Clifton, N.J.)
|January 25, 2018
PubMed
Summary

Metabolomics, the study of metabolites, reveals how metabolic processes impact immune cell function and immune responses. This approach aids in identifying biomarkers for immune-mediated diseases and advancing cellular immunometabolism research.

Keywords:
Cellular metabolismImmune cellsImmunometabolismMass spectrometryMetabolite tracingNMR

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Area of Science:

  • Immunology and Metabolism
  • Biochemistry and Systems Biology

Background:

  • Metabolic processes significantly influence immune cell function and immune response outcomes.
  • Understanding these metabolic underpinnings is crucial for deciphering immune system operations.

Purpose of the Study:

  • To review recent immunological studies utilizing metabolomics.
  • To highlight the contributions of metabolomics to cellular immunometabolism.
  • To discuss future prospects of metabolomic tools in immunology.

Main Methods:

  • Mass spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy-based platforms.
  • Metabolite characterization and quantification in biological samples.

Main Results:

  • Metabolomics has provided novel insights into immune system functioning.
  • Metabolomic approaches have aided in identifying biomarkers for immune-mediated diseases.
  • Significant contributions to the field of cellular immunometabolism have been made.

Conclusions:

  • Metabolomics is a powerful tool for understanding immune cell metabolism.
  • Future applications of metabolomic tools hold great promise for immunology and disease biomarker discovery.