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Low prevalence of mupirocin resistance in Staphylococcus pseudintermedius isolates from canine pyoderma in Korea

Ji-Hyung Park1, Jung-Hun Kang1, Jae-Eun Hyun1

  • 1Laboratory of Veterinary Dermatology, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea.

Veterinary Dermatology
|January 25, 2018
PubMed
Abstract

Insights

High-level mupirocin resistance in Staphylococcus pseudintermedius was detected in a pet dog with pyoderma. This finding highlights the importance of ongoing surveillance for antibiotic resistance in veterinary medicine.

Area of Science:

  • Veterinary Dermatology
  • Antimicrobial Resistance
  • Molecular Biology

Background:

  • Mupirocin is a topical antibiotic crucial for treating staphylococcal infections, including meticillin-resistant Staphylococcus pseudintermedius (MRSP).
  • The increasing prevalence of mupirocin resistance globally poses a significant challenge in both human and veterinary medicine.

Purpose of the Study:

  • To determine the occurrence and genetic basis of mupirocin resistance in Staphylococcus pseudintermedius isolated from dogs diagnosed with pyoderma.
  • To investigate the genotypic characteristics associated with mupirocin resistance in these isolates.

Main Methods:

  • Collected 110 clinical isolates of Staphylococcus pseudintermedius from client-owned dogs with pyoderma between July 2010 and September 2016.
  • Assessed low- and high-level mupirocin resistance using broth microdilution and disk diffusion assays.
  • Confirmed mupirocin resistance by genetically analyzing the ileS-2 and naïve ileS genes.

Main Results:

  • Identified meticillin-resistant Staphylococcus pseudintermedius (MRSP) in 69 dogs and meticillin-susceptible S. pseudintermedius in 41 dogs.
  • One MRSP isolate exhibited high-level mupirocin resistance, carrying the ileS-2 gene; no low-level resistant isolates were found.
  • The resistant MRSP strain was identified despite no prior exposure to mupirocin.

Conclusions:

  • Mupirocin remains an effective topical treatment for MRSP infections in dogs.
  • The emergence of high-level mupirocin resistance in an MRSP isolate, even without prior drug exposure, underscores the need for vigilant monitoring.
  • Continuous surveillance for mupirocin resistance is essential in small animal veterinary practice to guide treatment strategies and prevent further resistance spread.

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