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Increased psoriasis frequency in patients with familial Mediterranean fever

Abdulsamet Erden1, Ezgi Deniz Batu2, Emrah Seyhoğlu3

  • 1a Division of Rheumatology, Department of Internal Medicine , Hacettepe University Faculty of Medicine , Ankara , Turkey.

Upsala Journal of Medical Sciences
|January 25, 2018
PubMed
Abstract

Insights

Psoriasis is more common in patients with Familial Mediterranean fever (FMF) than in the general population. Clinicians should screen FMF patients for psoriasis and inquire about family history of the condition.

Area of Science:

  • Rheumatology
  • Dermatology
  • Genetics

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease characterized by recurrent episodes of fever and inflammation.
  • FMF is caused by mutations in the MEFV gene.
  • A potential association between FMF and psoriasis has been observed in some individuals.

Purpose of the Study:

  • To determine the prevalence of psoriasis among patients diagnosed with Familial Mediterranean fever (FMF).
  • To compare the prevalence of psoriasis in FMF patients and their relatives against the general population.
  • To investigate potential correlations between FMF and psoriasis in a specific cohort.

Main Methods:

  • A cohort of 351 FMF patients (177 adults, 174 children) was evaluated.
  • Psoriasis diagnosis in FMF patients and their relatives was confirmed by a dermatologist.
  • Data collection occurred between January and August 2016 at Hacettepe University Rheumatology Departments.

Main Results:

  • Psoriasis was diagnosed in 3.7% of FMF patients, a higher prevalence than the 0.42% in the general Turkish population.
  • Psoriasis was more frequent in adult FMF patients (11/177) compared to pediatric patients (2/174).
  • The prevalence of psoriasis among relatives of FMF patients was 12.4% in adults and 5.2% in children, with 8.8% of families having at least one member with psoriasis.

Conclusions:

  • Psoriasis occurs more frequently in individuals with FMF than in the general population.
  • Healthcare providers should actively screen FMF patients for psoriasis and assess their family history.
  • Further prospective, multicenter studies are recommended to establish the incidence of psoriasis in FMF patients.
Keywords:
Epidemiologyfamilial Mediterranean feverpsoriasisrheumatology

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