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Association between ABO blood types and pain perception.

Amalie Højmose Simoni1, Anne Jerwiarz1, Amalie Randers1

  • 1a Department of Health Science and Technology , Faculty of Medicine, Aalborg University , Aalborg East , Denmark.

Somatosensory & Motor Research
|January 25, 2018
PubMed
Summary

ABO blood type influences pain perception. Blood type B individuals showed lower pain sensitivity, while blood type AB individuals exhibited a stronger response to cold pain stimuli, suggesting blood type is a factor in pain research.

Keywords:
ABO blood typescold pressor testpainpain perceptionpain thresholdsex

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Area of Science:

  • Pain perception research
  • Human physiology
  • Immunogenetics

Background:

  • Pain perception is influenced by various phenotypic traits, including sex and pigmentation.
  • The potential impact of ABO blood type on pain sensitivity remains underexplored.

Purpose of the Study:

  • To investigate the hypothesis that ABO blood type affects pain perception.
  • To determine if blood type influences pressure pain thresholds and response to cold stimuli.

Main Methods:

  • Experimental study involving 37 healthy volunteers (18-40 years).
  • Assessment of pressure pain thresholds at temporalis, masseter, and deltoid muscles.
  • Inclusion of a cold pressor test involving immersion of the hand in iced water.

Main Results:

  • Blood type B participants demonstrated the highest pressure pain thresholds in craniofacial muscles.
  • Blood type AB participants exhibited the lowest pressure pain thresholds and the greatest increase after the cold pressor test.
  • Blood type AB group showed the strongest conditioned pain modulation effect.

Conclusions:

  • ABO blood type is associated with variations in mechanical pain sensitivity.
  • Blood type AB individuals display enhanced conditioned pain modulation.
  • ABO blood type should be considered in future pain research and clinical assessments.