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Updated: Feb 15, 2026

Local Application of Drugs to Study Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices
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Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine

Katarzyna M Targowska-Duda1, Agnieszka A Kaczor2,3, Krzysztof Jozwiak1

  • 1a Department of Biopharmacy , Medical University of Lublin , Lublin , Poland.

Journal of Biomolecular Structure & Dynamics
|January 25, 2018
PubMed

Keywords:
5-HI: 5-hydroxyindoleACh: acetylcholineAChBP: acetylcholine binding proteinECD: extracellular domainLY-2087101: [2-(4-fluoro-phenylamino)-4-methyl-thiazol-5-yl]-thiophen-3-yl-methanoneNS-1738: 1-(5-chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-ureaPAM-2: 3-furan-2-yl-N-p-tolyl-acrylamidePAM: positive allosteric modulatorPNU-120596: 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-isoxazol-3-yl)-ureaTBS-516: 4-(5-benzyl-3-(4-bromophenyl)-1H-1,2,4-triazol-1-yl)benzenesulfonamideTMD: transmembrane domainm5-HTR: murine serotonin type 3A receptormolecular dockingmolecular dynamicsnAChR: nicotinic acetylcholine receptornicotinic acetylcholine receptorpLGICs: pentameric ligand-gated ion channelstype I and type II positive allosteric modulatorsα7 PAMs

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