Related Experiment Video

Updated: Feb 15, 2026

Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium
16:47

Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium

Published on: February 27, 2011

51.3K

Sparfloxacin-induced nail pigmentation: A case of fixed drug eruption?

Husain Yahya1

  • 1Dermatology Unit, Department of Medicine, Barau Dikko Teaching Hospital, Kaduna, Nigeria.

Annals of African Medicine
|January 25, 2018
PubMed

Insights

Sparfloxacin, an antibiotic for respiratory infections, can cause blue-black nail pigmentation. This case report suggests it may be a fixed drug eruption, highlighting a rare side effect of this aminodifluoroquinolone.

Area of Science:

  • Pharmacology
  • Dermatology
  • Infectious Diseases

Background:

  • Sparfloxacin is a broad-spectrum aminodifluoroquinolone antibiotic with efficacy against respiratory pathogens.
  • Its clinical use is constrained by a higher incidence of phototoxicity compared to other quinolones.
  • Drug-induced nail pigmentation is a recognized, though less common, adverse effect of certain medications.

More Related Videos

Quantifying Abdominal Pigmentation in Drosophila melanogaster08:41

Quantifying Abdominal Pigmentation in Drosophila melanogaster

Published on: June 1, 2017

9.5K
Author Spotlight: Efficient Isolation of Primary Retinal Pigment Epithelial Cells from Adult Mice for Retinopathy Research05:04

Author Spotlight: Efficient Isolation of Primary Retinal Pigment Epithelial Cells from Adult Mice for Retinopathy Research

Published on: May 24, 2024

2.5K

Related Concept Videos

Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
3.5K
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.5K
Fixed Action Patterns01:06

Fixed Action Patterns

A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
15.0K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

4.5K
Growth versus Fixed Mindset01:24

Growth versus Fixed Mindset

Carol Dweck introduced the term mindset to describe individuals' beliefs about their intellectual and personal capabilities. These beliefs significantly influence psychological processes such as motivation, goal-setting, and perseverance, ultimately shaping academic and life outcomes. Individuals generally possess one of two mindsets- a fixed or a growth mindset—each promoting different responses to success, failure, and challenge.Fixed vs. Growth MindsetA fixed mindset assumes that one's...
329