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Related Experiment Video

Updated: Feb 15, 2026

Glycopeptide Capture for Cell Surface Proteomics

Glycopeptide Capture for Cell Surface Proteomics

Published on: May 9, 2014

Developments in Glycopeptide Antibiotics.

Mark A T Blaskovich^1,2, Karl A Hansford^1,2, Mark S Butler^1,2

¹Institute for Molecular Bioscience , The University of Queensland , 306 Carmody Road , Brisbane , Queensland 4072 , Australia.

ACS Infectious Diseases

|January 25, 2018

Summary

This summary is machine-generated.

Next-generation glycopeptide antibiotics show promise for combating drug-resistant Gram-positive bacteria. Further development is crucial to maintain effective treatments against evolving infections like MRSA.

Keywords:

antibiotics antimicrobial resistance glycopeptides vancomycin

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Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

Area of Science:

Microbiology
Pharmacology
Medicinal Chemistry

Background:

Glycopeptide antibiotics (GPAs) are vital for treating Gram-positive bacterial infections.
Vancomycin remains a primary therapy, but resistance necessitates new agents.
Emerging semisynthetic GPAs like dalbavancin and oritavancin offer improved efficacy against resistant strains.

Purpose of the Study:

To review the development and potential of next-generation glycopeptide antibiotics.
To highlight the need for continued innovation in GPA development due to rising antibiotic resistance.
To assess the readiness of novel GPAs for clinical advancement.

Main Methods:

Review of recent literature on GPA synthesis and characterization.
Analysis of pharmacokinetic (PK) and pharmacodynamic (PD) profiles of novel GPAs.
Evaluation of in vivo efficacy and preclinical safety data.

Main Results:

Numerous modified glycopeptides have been generated through total synthesis, semisynthesis, and biological engineering.
Several candidates demonstrate promising in vivo efficacy, favorable PK/PD profiles, and no preclinical toxicity.
These next-generation GPAs are technically poised for clinical development.

Conclusions:

Next-generation glycopeptides represent a critical advancement in the fight against multidrug-resistant Gram-positive bacteria.
Sufficient funding and market support are essential to advance these promising agents to clinical application.
Continued investment in antibiotic development is necessary to sustain the Gram-positive therapeutic arsenal.