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    This study introduces novel symbol synchronization schemes for molecular communication (MC) systems, addressing variable symbol interval lengths. The developed methods improve data detection accuracy in practical nanotransmitter scenarios.

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    Area of Science:

    • Biomedical Engineering
    • Communication Systems
    • Nanotechnology

    Background:

    • Symbol synchronization is crucial for reliable data detection in communication systems.
    • Molecular Communication (MC) systems face unique challenges, including transmitters lacking internal clocks and fixed release frequencies.
    • Practical nanotransmitters, like modified cells, exhibit variable symbol interval lengths due to biological and environmental factors.

    Purpose of the Study:

    • To develop robust symbol synchronization schemes for MC systems with variable symbol interval lengths.
    • To address practical limitations of nanotransmitters, such as lack of internal clocks and irregular molecule release.
    • To propose low-complexity synchronization methods suitable for resource-constrained MC systems.

    Main Methods:

    • Developed two synchronization-detection frameworks utilizing two types of molecules.
    • Derived optimal Maximum Likelihood (ML) synchronization schemes as performance benchmarks.
    • Proposed three low-complexity suboptimal schemes: linear filter-based, peak observation-based, and threshold-trigger.
    • Analyzed scheme complexity, constraints, and the impact of insertion/deletion errors.

    Main Results:

    • Simulation results demonstrate the effectiveness of the proposed symbol synchronization schemes.
    • The accuracy of symbol synchronization was shown to significantly impact the end-to-end performance of MC systems.
    • Suboptimal schemes offer practical, low-complexity alternatives to ML synchronization for MC.

    Conclusions:

    • The developed symbol synchronization schemes effectively address practical challenges in MC systems.
    • Accurate symbol synchronization is a critical factor for reliable data transmission in MC.
    • The proposed low-complexity schemes are suitable for MC systems with limited computational resources.