Related Experiment Videos
"Maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin
Alberto Consolaro1,2, Maurício Almeida Cardoso3, Renata Bianco Consolaro4
1Universidade de São Paulo, Faculdade de Odontologia de Bauru (Bauru/SP, Brazil).
Dental Press Journal of Orthodontics
|January 25, 2018
Summary
Maxillary lateral incisor anodontia is not a genetic syndrome but an epigenetic sequence. Its absence causes palatal canine displacement and subsequent dental anomalies.
Area of Science:
- Dentistry
- Genetics
- Developmental Biology
Background:
- Maxillary lateral incisor anodontia and palatal canine displacement are observed together.
- This association has been previously considered a potential genetic syndrome.
Purpose of the Study:
- To investigate the etiological basis of the association between maxillary lateral incisor anodontia and palatal canine displacement.
- To propose a new classification for this clinical presentation.
Main Methods:
- Review of existing literature and clinical case observations.
- Analysis of potential genetic and epigenetic factors.
Main Results:
- No specific genes or chromosomal locations were identified for this condition, ruling out a defined genetic etiology.
- The absence of maxillary lateral incisors appears to create an environmental change, influencing canine eruption path.
- This leads to a sequence of developmental anomalies, including palatal displacement, malocclusion, and other dental issues.
Conclusions:
- The condition is best described as a sequence of developmental anomalies, termed "Maxillary Lateral Incisor Partial Anodontia Sequence."
- An epigenetic etiology is proposed, driven by the absence of the lateral incisor impacting canine eruption trajectory.
- This reclassification emphasizes the sequential nature and environmental influences rather than a genetic syndrome.