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Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients.

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Childhood vitiligo onset is common. This study found prepubertal vitiligo in Arabs is more common in females and involves the face more often, while stress is a key factor in postpubertal vitiligo.

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Area of Science:

  • Dermatology
  • Pediatric Dermatology
  • Autoimmune Diseases

Background:

  • Vitiligo commonly begins in childhood, with limited comparative data on clinical associations between prepubertal and postpubertal onset in Arab populations.
  • Understanding these differences is crucial for targeted management and research.

Purpose of the Study:

  • To compare the clinical profiles and associations of vitiligo with prepubertal versus postpubertal onset.

Main Methods:

  • A cross-sectional observational study involving 375 patients.
  • Data collected using the Vitiligo European Task Force questionnaire.

Main Results:

  • Female gender, halo nevus presence, and facial involvement were significantly associated with prepubertal vitiligo onset.
  • Stress was more frequently reported as an onset factor in the postpubertal vitiligo group.
  • Prepubertal vitiligo showed higher disease involvement compared to postpubertal onset.

Conclusions:

  • Vitiligo exhibits similar behavior in both prepubertal and postpubertal groups, with distinct demographic and clinical associations.
  • Female over-representation, facial involvement, and halo nevi characterize prepubertal vitiligo.
  • Stress is a more prevalent aggravating factor in postpubertal vitiligo.