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Keeping Track of the Electrons
Erika L Lucas1, Elizabeth R Jarvo1
1Department of Chemistry, University of California , Irvine, California 92697-2025, United States.
Accounts of Chemical Research
|January 25, 2018
Summary
Mechanistic studies of nickel-catalyzed stereoselective alkyl cross-coupling reactions are challenging but crucial. Chemical intuition and experiments pave the way for discovering new base metal-catalyzed transformations.
Area of Science:
- Organic chemistry
- Catalysis
Background:
- Mechanistic investigation and reaction development are interdependent.
- Base metal catalysts offer unique reactivity but are mechanistically challenging compared to precious metals.
Purpose of the Study:
- Highlight the developing field of nickel-catalyzed stereoselective alkyl cross-coupling reactions.
- Discuss the challenges and opportunities in understanding these reactions.
Main Methods:
- Review of key mechanistic experiments.
- Application of chemical intuition to guide discovery.
Main Results:
- Nickel catalysts enable stereoselective alkyl cross-coupling.
- Understanding of catalytic cycles remains incomplete.
Conclusions:
- Despite mechanistic ambiguities, significant progress has been made in nickel-catalyzed stereoselective alkyl cross-coupling.
- Further mechanistic studies are needed to fully unlock the potential of base metal catalysis.
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