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Updated: Feb 15, 2026
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
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Mass Exchange and Equilibration Processes in AOT Reverse Micelles
Gozde Eskici1, Paul H Axelsen2
1Department of Biochemistry & Biophysics, University of Pennsylvania Perelman School of Medicine , Philadelphia 19104, United States.
Langmuir : the ACS Journal of Surfaces and Colloids
|January 25, 2018
Summary
Reverse micelles (RMs) mass transfer occurs via transient fusion, not diffusion. Amyloid beta peptides influence RM size and stability during fusion events, highlighting their interaction with surfactant layers.
Area of Science:
- Physical Chemistry
- Biophysics
- Materials Science
Background:
- Reverse micelles (RMs) are vital experimental models for aqueous microenvironments.
- Understanding RM size determinants is crucial for their application.
- Sodium bis(2-ethylhexyl)sulfosuccinate in isooctane are common RM models.
Purpose of the Study:
- Investigate factors influencing reverse micelle size.
- Explore mass transfer mechanisms between RMs.
- Analyze the role of amyloid beta peptides in RM dynamics.
Main Methods:
- All-atom molecular dynamics simulations on Anton 2 supercomputer.
- Simulations of RMs with varying sizes and constant water-loading ratio.
- Observation of microsecond timescale events and mass exchange.
Main Results:
- No net water diffusion observed between RMs of different sizes.
- Mass transfer occurs primarily through transient fusion events.
- RM fusion requires water at contact points; amyloid beta peptides terminate fusion and alter RM size.
Conclusions:
- Transient fusion, not diffusion, is the primary mass transfer mechanism between RMs.
- Amyloid beta peptides interact with and influence surfactant layers, affecting RM behavior.
- RM size can increase during fusion events involving peptides, independent of water-loading ratio.
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