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Serum calcification propensity is independently associated with disease activity in systemic lupus erythematosus

Suzan Dahdal1, Vasilios Devetzis1, George Chalikias2

  • 1Department of Nephrology and Hypertension lnselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Plos One
|January 25, 2018
PubMed

Insights

The T50 score, a novel blood test for calcification propensity, is closely associated with disease activity in Systemic Lupus Erythematosus (SLE) patients. This finding suggests T50 may serve as an early biomarker for identifying high-risk SLE individuals.

Area of Science:

  • Rheumatology
  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Systemic lupus erythematosus (SLE) is linked to significant cardiovascular issues.
  • The T50 score quantifies serum calcification propensity, a predictor of mortality.
  • High calcification propensity (low T50) is a key mortality determinant.

Purpose of the Study:

  • To investigate the association between T50 score and disease activity in SLE patients.
  • To evaluate T50 as a potential biomarker for SLE.
  • To identify high-risk SLE patients using T50 levels.

Main Methods:

  • Analysis of 168 SLE patients from the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS).
  • Assessment of serum calcification propensity using time-resolved nephelometry (T50 score).
  • Correlation analysis with disease activity using SELENA-SLEDAI scores.

Main Results:

  • The T50 score was influenced by hemoglobin, creatinine, and protein levels.
  • Disease activity (SELENA-SLEDAI) was significantly associated with T50 levels.
  • A negative association was observed between T50 and SELENA-SLEDAI in patients with active disease (rho = -0.233, P = 0.02).

Conclusions:

  • T50 levels are closely associated with SLE disease activity.
  • T50 identifies SLE patients with active systemic inflammation.
  • T50 shows promise as a biomarker for SLE activity and early risk detection.
Abstract

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