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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

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Related Experiment Video

Updated: Jun 18, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

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Published on: July 14, 2016

Slower saccadic reading in Parkinson's disease.

Naz Jehangir1, Caroline Yizhu Yu1, Jeehey Song1

  • 1Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, United States of America.

Plos One
|January 25, 2018
PubMed
Summary

Parkinson's disease (PD) patients exhibit slower saccadic reading compared to controls. Visual crowding and irregular spacing significantly impact reading speed in both groups, suggesting a potential screening tool for ocular motor deficits in PD.

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Last Updated: Jun 18, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Idiopathic Parkinson's Disease (PD) involves neuronal degeneration, causing motor and non-motor symptoms.
  • Abnormal eye movements are common in PD, but saccadic reading has been understudied.
  • Saccadic reading is crucial for daily activities and quality of life.

Purpose of the Study:

  • To assess saccadic reading abilities in Parkinson's disease patients.
  • To compare reading performance between PD patients and age-matched controls.
  • To identify factors influencing saccadic reading speed in PD.

Main Methods:

  • Utilized variations of the King-Devick (KD) test for rapid number naming.
  • Recruited 42 treated PD patients and 80 controls.
  • Collected data on reading times, age, disease duration, UPDRS, VFQ-25, and MoCA scores.

Main Results:

  • PD patients were approximately 20% slower in saccadic reading than controls.
  • Both groups were slower with irregularly spaced numbers and increased visual crowding.
  • Reading time correlated with age, disease duration, and visual functioning (VFQ-25), but not UPDRS or MoCA.

Conclusions:

  • Saccadic reading is impaired in Parkinson's disease.
  • Visuospatial challenges like crowding and irregular spacing affect reading in both PD patients and controls.
  • A simple reading test may serve as a clinical screening tool for ocular motor deficits in PD.