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Drug Shortages: Effect on Parenteral Nutrition Therapy
Beverly Holcombe1, Todd W Mattox2, Steve Plogsted3
1American Society for Parenteral and Enteral Nutrition, Silver Spring, Maryland, USA.
Summary
Drug shortages, particularly of sterile injectable components for parenteral nutrition (PN), threaten patient health. Managing complex PN formulations during shortages requires careful attention to prevent medication errors and ensure patient safety.
Area of Science:
- Clinical Pharmacy
- Patient Safety
- Healthcare Management
Background:
- Drug shortages are a significant threat to patient health in the U.S.
- Parenteral nutrition (PN) patients are at increased risk due to shortages of sterile injectable components.
- PN therapy is complex, involving numerous ingredients, making it vulnerable to supply chain disruptions.
Purpose of the Study:
- To highlight the challenges posed by drug shortages on parenteral nutrition (PN) therapy.
- To emphasize the critical need for considering PN component availability throughout the entire treatment process.
- To underscore the potential for medication errors and adverse patient outcomes due to PN supply issues.
Main Methods:
- Review of current drug shortage data focusing on sterile injectables.
- Analysis of the complexity of parenteral nutrition (PN) formulation and administration.
- Examination of the PN use process from prescription to patient administration.
Main Results:
- Sterile injectables constitute a substantial portion (approximately 75%) of active drug shortages.
- The multi-ingredient nature of PN complicates management during shortages.
- Deviations from standardized PN processes can lead to medication errors.
Conclusions:
- Ensuring the availability of PN components is crucial for safe and effective patient care.
- Robust strategies are needed to mitigate the impact of drug shortages on PN therapy.
- Proactive management of PN component supply is essential to prevent adverse patient events and optimize healthcare resource utilization.
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