Related Experiment Video
Updated: Feb 15, 2026
11:11
Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
Published on: February 8, 2016
23.5K
Case report: an identical twin with Sertoli-Leydig cell tumor
Kristy Cho1, Jon C Havelock1,2, Blake Gilks3
1a Department of Obstetrics and Gynaecology, Division of Reproductive Endocrinology and Infertility , University of British Columbia , Vancouver , Canada.
Summary
A rare Sertoli-Leydig cell tumor (SLCT) was diagnosed in a woman with virilization. Genetic testing for the DICER1 mutation was crucial for her identical twin's management.
Area of Science:
- Endocrinology
- Gynecologic Oncology
- Medical Genetics
Background:
- Sertoli-Leydig cell tumors (SLCTs) are rare sex-cord ovarian neoplasms.
- They can cause significant hormonal disturbances, including virilization and amenorrhea.
- SLCTs are associated with an increased risk of endometrial hyperplasia and malignancy.
Observation:
- A 43-year-old woman presented with a 2-year history of virilization and secondary amenorrhea.
- Elevated serum total testosterone was noted, but imaging failed to identify adnexal or adrenal masses.
- Ovarian vein sampling revealed unilateral testosterone hypersecretion.
Findings:
- Laparoscopic unilateral oophorectomy confirmed the diagnosis of SLCT.
- The patient's identical twin underwent DICER1 mutation testing, which was essential for her clinical management.
- This case highlights the importance of considering genetic factors, such as the DICER1 mutation, in the context of SLCT.
Implications:
- This case underscores the diagnostic challenges and management strategies for androgen-secreting ovarian tumors.
- It emphasizes the clinical significance of the DICER1 mutation in familial cases of SLCT.
- Early identification and management are crucial due to the potential for associated endometrial pathology and malignancy.
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