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Study on the mechanism of the long-lasting antagonistic effect of caerulein on amphetamine-induced hyperactivity in
General Pharmacology
|January 1, 1986
Abstract:
The long-lasting antagonistic effect of caerulein (CLN) on amphetamine (AMP) hyperactivity was abolished in rats following partial 6-OHDA lesions of the nucleus accumbens (NA) or dopamine (DA) A10 area. CLN showed the long-term antagonistic effect on AMP hyperactivity in rats following complete 6-OHDA lesions of the DA A9 area. Neonatal monosodium L-glutamate-treated rats did not show the CLN effect. These results suggest that opiate receptors presynaptically located on DA neurons in the NA and some modulatory changes in the beta-endorphin system in the arcuate nucleus may play an important role in producing the CLN effect.