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Prognostic value of microRNA-155 in human carcinomas: An updated meta-analysis

Kangkang Liu1, Kun Zhao1, Lining Wang1

  • 1Department of Urology, Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin 300211, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 26, 2018
PubMed
Abstract

Insights

Increased microRNA-155 (miR-155) expression correlates with poorer survival in human cancers. This finding suggests miR-155 may serve as a valuable prognostic biomarker for various carcinoma outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • MicroRNA-155 (miR-155) exhibits dual roles as an oncomiR or oncosuppressor in human cancers.
  • The prognostic significance of miR-155 across different cancer types remains uncertain.

Purpose of the Study:

  • To systematically evaluate the prognostic value of miR-155 in human cancers.
  • To determine the association between miR-155 expression levels and patient survival outcomes.

Main Methods:

  • A comprehensive literature search was conducted in PubMed and Embase.
  • Meta-analysis of combined hazard ratios (HR) was performed on data from 24 relevant studies.

Main Results:

  • Elevated miR-155 expression was significantly linked to poorer overall survival (OS) (HR = 1.99).
  • Increased miR-155 was also associated with reduced progression-free survival (PFS)/recurrence-free survival (RFS)/disease-free survival (DFS) (HR = 1.95).
  • A trend towards poorer cancer-specific survival (CSS)/disease-specific survival (DSS) was observed (HR = 2.50).

Conclusions:

  • Higher miR-155 expression is associated with adverse survival outcomes in human carcinoma.
  • miR-155 demonstrates potential as a predictive biomarker for patient prognosis in cancer.
Keywords:
Human carcinomasMeta-analysisMiR-155Prognosis

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