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The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases

Zhe Chen1, Lu He1, Lanfang Li1

  • 1Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 26, 2018
PubMed

Insights

The P2X7 receptor, a key player in cell signaling, impacts cardiovascular health. Research explores its dual role in conditions like heart attack and atherosclerosis, highlighting its therapeutic potential.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Immunology

Background:

  • The P2X7 receptor is an ATP-gated ion channel involved in various physiological processes.
  • Its role in cardiovascular diseases is increasingly recognized, with evidence suggesting both protective and detrimental effects.
  • Understanding P2X7 receptor function is crucial for developing novel cardiovascular therapies.

Purpose of the Study:

  • To review the latest research on the P2X7 receptor's involvement in cardiovascular diseases.
  • To explore the therapeutic potential of targeting the P2X7 receptor for cardiovascular conditions.

Main Methods:

  • Literature review of studies investigating P2X7 receptor in cardiovascular contexts.
  • Analysis of experimental data on P2X7 receptor activation and inhibition in models of cardiovascular disease.

Main Results:

  • P2X7 receptor activation can attenuate myocardial ischemia-reperfusion injury.
  • Inhibition of P2X7 receptor shows benefits in arrhythmia, cardiac transplantation, cardiomyopathy, and autoimmune myocarditis.
  • The P2X7 receptor influences vascular diseases such as atherosclerosis, hypertension, thrombosis, and diabetic retinopathy.

Conclusions:

  • The P2X7 receptor has a significant and complex role in cardiovascular health and disease.
  • Targeting the P2X7 receptor presents a promising therapeutic avenue for various cardiovascular and vascular conditions.
Keywords:
AtherosclerosisAutoimmune myocarditisDiabetic retinopathyDilated cardiomyopathyMyocardial ischemia-reperfusion injuryThe P2X7 receptor

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