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Internal validation of STRmix™ - A multi laboratory response to PCAST
Jo-Anne Bright1, Rebecca Richards1, Maarten Kruijver1
1Institute of Environmental Science and Research Limited, Private Bag 92021, Auckland, 1142, New Zealand.
Abstract:
We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.
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