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The critical roles of TBC proteins in human diseases

Meng-Ting Shi1, Ying Zhang2, Gang-Qiao Zhou2

  • 1Graduate School, Guangxi Medical University, Nanning 530021, China; National Center for Protein Sciences, the State Key Lab of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China.

Yi Chuan = Hereditas
|January 26, 2018
PubMed

Insights

The Tre-2/Bub2/Cdc16 (TBC) domain proteins regulate intracellular trafficking by activating small GTPase Rab. Dysfunctional TBC proteins are linked to human diseases, highlighting their critical roles.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The Tre-2/Bub2/Cdc16 (TBC) domain is a conserved protein motif found in eukaryotes.
  • TBC domain-containing proteins (TBC proteins) act as GTPase activating proteins (GAPs) for Rab GTPases.
  • Rab GTPases are crucial regulators of intracellular trafficking pathways.

Purpose of the Study:

  • To review the structures and functions of mammalian TBC proteins.
  • To summarize recent advances in understanding the roles of TBC proteins in human diseases.
  • To provide a reference for future research on TBC proteins in disease pathogenesis.

Main Methods:

  • Literature review of structural and functional studies on mammalian TBC proteins.
  • Analysis of recent research on the involvement of TBC proteins in human diseases.
  • Synthesis of information regarding TBC protein mechanisms and disease associations.

Main Results:

  • Mammalian TBC proteins exhibit diverse structures and functions.
  • TBC proteins are implicated in various cellular processes.
  • Defects in TBC proteins are associated with numerous human diseases.

Conclusions:

  • Mammalian TBC proteins are essential for cellular functions and intracellular trafficking.
  • Understanding TBC protein structure and function is critical for deciphering their roles in disease.
  • Further investigation into TBC proteins offers potential for disease therapeutic strategies.

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