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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Principles of Disease Surveillance01:26

Principles of Disease Surveillance

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Related Experiment Video

Updated: Feb 15, 2026

Detection of Protein Ubiquitination
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Detection of Protein Ubiquitination

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[Autoimmune diseases and ubiquitin system].

Shigeru Oshima1

  • 1Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU).

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|January 26, 2018
PubMed
Summary

Understanding the ubiquitin system

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Cytokines are crucial in autoimmune disease pathogenesis.
  • Anti-tumor necrosis factor alpha (TNFα) therapies show promise for rheumatoid arthritis, Crohn's disease, and psoriasis.
  • Genome-wide association studies (GWAS) have identified numerous autoimmune disease susceptibility loci.

Purpose of the Study:

  • To review recent advances in understanding TNFR signaling via the ubiquitin system.
  • To highlight the roles of TNFAIP3 and TNIP1 in ubiquitin-dependent signaling.
  • To introduce a novel assay for visualizing ubiquitin chain dynamics.

Main Methods:

  • Review of current literature on TNFR signaling and ubiquitin pathways.
  • Focus on genes TNFAIP3 and TNIP1 implicated in autoimmune diseases.
Keywords:
TNFAIP3 (A20)TNFαTNIP1 (ABIN-1)autoimmune diseaseubiquitin

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  • Development and description of a polyubiquitin-mediated fluorescence complementation (PolyUb-FC) assay.

    • Main Results:

    • TNFAIP3 and TNIP1 are linked to multiple autoimmune diseases.
    • These genes regulate crucial ubiquitin-dependent signaling pathways.
    • The PolyUb-FC assay allows visualization of chain-specific poly-ubiquitination in vivo.
    • Monoubiquitination is non-fluorescent, enabling clear visualization of polyubiquitin chains.

    Conclusions:

    • TNFAIP3 and TNIP1 play significant roles in autoimmune disease pathogenesis through ubiquitin regulation.
    • The PolyUb-FC assay is a valuable tool for studying ubiquitin chain dynamics in living cells.
    • Further research into ubiquitin-mediated signaling offers therapeutic potential for autoimmune diseases.