Vascular Development and Regeneration in the Mammalian Heart

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Oscar M Leung1,2, Bin Zhou3,4,5, Kathy O Lui6,7

  • 1Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China. oscar5292003@yahoo.com.hk.

Journal of Cardiovascular Development and Disease
|January 26, 2018
PubMed

Insights

Understanding the origin of coronary vessels is key to treating heart disease. Research reveals diverse sources for these vital blood vessels, offering new therapeutic avenues.

Area of Science:

  • Cardiovascular biology and developmental origins of cardiac structures.

Background:

  • Cardiovascular diseases, including coronary artery disease, represent a primary global cause of mortality.
  • Identifying the developmental origins of coronary vessels is crucial for advancing cardiovascular disease treatments.

Purpose of the Study:

  • To review recent advancements in understanding the sources of coronary vessels in the mammalian heart.
  • To discuss the potential of VEGF-modified mRNAs for inducing therapeutic neovascularization in damaged hearts.

Main Methods:

  • Utilizing lineage-tracing models to determine the origin of coronary vessels.
  • Employing differentiation studies with pluripotent stem cells to investigate vessel development.
  • Exploring transient expression of VEGF-modified mRNAs for neovascularization.

Main Results:

  • The endocardial source of coronary vessels has been identified, indicating a heterogeneous origin in the adult heart.
  • Lineage tracing and stem cell differentiation studies provide insights into coronary vessel development.

Conclusions:

  • Advances in understanding coronary vessel origins offer significant therapeutic implications for cardiovascular diseases.
  • VEGF-modified mRNA technology presents a promising platform for inducing neovascularization and treating heart damage.

Keywords:
angiocrine factorsheart regenerationvascular developmentvascular endothelial cells

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