Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

642
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
642
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.0K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

966
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
966
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

402
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
402
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

1.0K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The limited role of genetics explaining the atherosclerotic process and coronary artery disease and the holistic perspective of systems biology.

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese·2018
Same author

Conceptual Foundations of Systems Biology Explaining Complex Cardiac Diseases.

Healthcare (Basel, Switzerland)·2017
Same author

Systems biology and clinical phenotypes of heart failure syndrome.

Journal of the American College of Cardiology·2015
Same author

Heart failure: a complex clinical process interpreted by systems biology approach and network medicine.

Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology·2014
Same author

Systems biology and biomechanical model of heart failure.

Current cardiology reviews·2012
Same author

A conceptual paradigm of heart failure and systems biology approach.

International journal of cardiology·2011

Related Experiment Video

Updated: Feb 15, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

2.1K

Heart Failure in Patients with Preserved Ejection Fraction: Questions Concerning Clinical Progression.

George E Louridas1, Katerina G Lourida2

  • 1Department of Cardiology, University General Hospital AHEPA, Aristotle University, Thessaloniki 54124, Greece. louridasg@gmail.com.

Journal of Cardiovascular Development and Disease
|January 26, 2018
PubMed
Summary

Understanding heart failure with preserved ejection fraction (HFpEF) progression from early diastolic dysfunction remains limited. Further research is needed to map this clinical journey and identify underlying cardiac remodeling mechanisms.

Keywords:
clinical phenotypes of heart failureheart failureheart failure progressionheart failure with preserved ejection fractionleft ventricular remodeling

More Related Videos

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.1K
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.4K

Related Experiment Videos

Last Updated: Feb 15, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

2.1K
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.1K
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.4K

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Clinical Progression Studies

Background:

  • Significant advances in understanding heart failure with preserved ejection fraction (HFpEF) pathophysiology have been made.
  • Knowledge gaps persist regarding the natural history of clinical progression from pre-clinical diastolic dysfunction (PDD) to established HFpEF.
  • The transition from PDD to HFpEF and subsequent progression to complex multi-organ involvement models are poorly understood.

Purpose of the Study:

  • To elucidate the natural history of clinical progression in patients with HFpEF.
  • To identify the specific left ventricular remodeling mechanisms driving HFpEF progression.

Main Methods:

  • Prospective studies are required to investigate the clinical progression of HFpEF.
  • Detailed analysis of left ventricular remodeling in HFpEF patients is necessary.

Main Results:

  • Current understanding of HFpEF progression from PDD is limited.
  • The progression pathways from PDD to HFpEF and to advanced stages are not well-defined.

Conclusions:

  • Prospective studies are essential to fully understand HFpEF natural history.
  • Identifying left ventricular remodeling mechanisms is critical for managing HFpEF progression.