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Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
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Single-cell variability in multicellular organisms.

Stephen Smith1, Ramon Grima2

  • 1School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JR, Scotland, UK.

Nature Communications
|January 26, 2018
PubMed
Summary
This summary is machine-generated.

Cell-cell coupling in multicellular organisms can alter gene expression noise, impacting tissue heterogeneity. This variability depends on genetic network properties and coupling strength, offering insights into biological noise control.

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Area of Science:

  • Systems Biology
  • Developmental Biology
  • Genetics

Background:

  • Noisy gene expression is crucial for single cells and well-studied in unicellular organisms.
  • Studying gene expression noise in multicellular organisms is complex due to cell-cell interactions within tissues.
  • Cell-cell coupling through various mechanisms prevents cells from being fully independent or entirely homogeneous.

Purpose of the Study:

  • To investigate how cell-cell coupling affects single-cell variability and tissue heterogeneity in multicellular organisms.
  • To determine the influence of genetic network properties on the relationship between coupling strength and noise.

Main Methods:

  • Utilizing spatial stochastic simulations of simple genetic networks.
  • Analyzing experimental data from both animal and plant tissues.

Main Results:

  • Increasing cell-cell coupling can either increase or decrease single-cell variability.
  • The effect of coupling on variability is contingent upon the statistical characteristics of the underlying genetic network.
  • Predictions were validated through simulations and experimental data.

Conclusions:

  • Cell-cell coupling is a significant factor influencing gene expression noise in multicellular tissues.
  • This coupling may represent a noise-control strategy employed by multicellular organisms.
  • Further research is needed to fully understand the role of cell-cell coupling in multicellular behavior and noise regulation.