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Updated: Feb 15, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Rapid clearance of erythrodermic psoriasis with apremilast
Evangelia Papadavid1, Georgios Kokkalis1, Georgios Polyderas1
12nd Deaprtment of Dermatology and Venereology, National and Kapodistrian University of Athens, ATTIKON Hospital, Greece.
Background:
Apremilast is a new immunomodulatory drug, a small molecule inhibitor of PDE4, which down-regulates the expression of multiple pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin 17, interleukin 23.
Main Observations:
We describe a case of a 54-year-old man with erythroderma in the course of psoriasis (PASI=49), with contraindications to other psoriasis therapies, in whom total clearance of skin lesions was achieved by day 20 after therapy with apremilast at a dose of 30 mg bid (ΔPASI = 100). The patient had a history of prior use of cyclosporine, methotrexate and adalimumab. His comorbidities included obesity, fatty liver and hypercholesterolemia.
Conclusion:
In this case of erythroderma in the course of psoriasis apremilast led to total clearance of all cutaneous lesions.
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