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Updated: Feb 15, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Genetic diversity of Orf virus isolated from sheep in Uruguay
Natalia Olivero1,2, Eduardo Reolon3,4, Juan Arbiza1
1Sección Virología, Facultad de Ciencias, UdelaR, Iguá 4225, 11400, Montevideo, Uruguay.
Abstract:
Orf virus (ORFV) is the etiological agent of contagious ecthyma, a disease widely spread in the world that occasionally causes zoonotic infections. This work is the first molecular characterization of ORFV in Uruguay, where we analyzed twenty-one sheep samples, eighteen of which were recovered from thirteen ORFV outbreaks that occurred during 2004 to 2011 as well as three strains from a national vaccine. Phylogenetic analysis and the derived amino acid sequences from the B2L gene suggest that the Uruguayan virus do not form a unique cluster, with most of them displaying similarities with worldwide ORFV isolates as well as our vaccine strains.
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