Related Experiment Videos
[Left ventricular peak filling velocity and its relevant factors in hypertrophic hearts]
Insights
Left ventricular peak filling velocity (Vf) and its normalized value (Vf/D) are significantly decreased in hypertrophic hearts (HTH) without congestive heart failure (CHF), indicating impaired diastolic function. These measures also decline with reduced systolic function in aortic stenosis and HTH with CHF.
Area of Science:
- Cardiology
- Biomedical Engineering
- Physiology
Context:
- Hypertrophic hearts (HTH) encompass conditions like hypertensive heart disease (HHD) and hypertrophic cardiomyopathy (HCM).
- Assessing left ventricular diastolic function is crucial for understanding cardiac health in HTH.
- Previous studies have focused on systolic function, with less emphasis on diastolic filling dynamics.
Purpose:
- To evaluate factors influencing left ventricular peak filling velocity (Vf) in patients with HTH.
- To compare diastolic and systolic function parameters between different HTH subgroups and normal subjects.
Summary:
- M-mode echocardiograms were analyzed in 81 HTH patients (HHD, HCM, aortic valve stenosis, and CHF) and 24 controls.
- Key parameters including Vf, Vf/D, and various systolic function indices were computed.
- Systolic function was preserved in HTH without CHF, but Vf and Vf/D were significantly reduced, suggesting diastolic impairment.
Impact:
- Findings highlight reduced diastolic filling velocity as a key indicator in HTH, even without overt congestive heart failure.
- Vf and Vf/D alterations correlate with structural and functional parameters, offering insights into disease mechanisms.
- This study provides a basis for further investigation into therapeutic strategies targeting diastolic dysfunction in HTH.
Abstract:
To evaluate the relevant factors of left ventricular peak filling velocity, M-mode echocardiograms showing the left ventricular cavity were recorded and digitized for 81 patients with hypertrophic hearts (HTH) due to hypertensive heart disease (HHD, n = 30), hypertrophic cardiomyopathy (HCM, n = 25), aortic valve stenosis (AS, n = 9), and HHD and HCM with congestive heart failure (HHD and HCM with CHF, n = 17). Peak rates of increase or decrease in dimension (Vf and Ve, respectively) and peak values of instantaneous circumferential fiber lengthening and shortening velocities (Vf/D and Ve/D, respectively) were determined by computer analysis of left ventricular internal dimensions. Systolic excursion (SE), percent fractional shortening (%FS), mean circumferential fiber shortening velocity (mVcf), thickness of the interventricular septum and posterior wall at end-diastole and the sum of them (WThivs, WThpw, and WThivs + pw, respectively) were also calculated. Their variables were compared with those of normal subjects (n = 24). The results obtained were as follows: Systolic functions in HTH without CHF were similar to those of the normal subjects, but Vf and Vf/D were significantly decreased. Differences in Vf and Vf/D between various HTH without CHF were not significant. In AS and HTH with CHF, Vf and Vf/D were significantly decreased together with systolic function. Vf correlated significantly with WThivs + pw, SE, Ve, and WThivs, and Vf/D with %FS, SE, Ve/D, and Ve.(ABSTRACT TRUNCATED AT 250 WORDS)