Related Experiment Video
Updated: Feb 15, 2026
09:31
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
9.3K
Visualization of viscoelastic behavior in skin equivalent using optical coherence tomography-based straingraphy.
Y Hara1,2, Y Ogura1, T Yamashita1
1Shiseido Research Center, Kanagawa, Japan.
Summary
Cultured skin equivalents (SEs) show increased mechanical specialization at the dermal-epidermal junction (DEJ) over time. Dynamic-optical coherence straingraphy (D-OCSA) reveals this, aiding SE quality assessment.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Biomechanical Engineering
Background:
- The mechanical roles of skin components remain poorly understood.
- Investigating the relationship between skin structure and mechanical function is crucial.
Purpose of the Study:
- To spatially map the mechanical behavior of cultured skin equivalents (SEs).
- To clarify the relationships between skin components and their mechanical functions using optical coherence tomography (OCT)-based straingraphy.
Main Methods:
- Developed dynamic-optical coherence straingraphy (D-OCSA) integrating OCT with a strain relaxation test system.
- Analyzed spatial mechanical changes in SEs based on culture duration.
- Defined a relaxation attenuation coefficient to quantify viscoelastic behavior.
Main Results:
- The strain relaxation attenuation coefficient significantly increased negatively at the dermal-epidermal junction (DEJ) after 4 days of culture compared to 1 day.
- Microscopic analysis revealed cracks in SEs cultured for 4 days.
- Demonstrated time-dependent spatial mechanical changes in SEs.
Conclusions:
- Provided quantified evidence that the DEJ is a dynamically specialized region.
- The OCT-based D-OCSA system is valuable for assessing SE quality and analyzing their mechanics.
Related Concept Videos
01:26Pharmaceutical Equivalents
208
As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
208
01:19Equivalent Capacitance
2.2K
Multiple capacitors can be connected in a circuit in series or parallel configuration. When the capacitor combination is connected to a battery, the potential drop across each capacitor and the magnitude of charge stored in the individual capacitor depends on the type of the connection. The capacitor combination is replaced by a single equivalent capacitor that stores the same amount of charge as the combination for a given potential difference.
The following strategies are adopted to calculate...
The following strategies are adopted to calculate...
2.2K
01:19Equivalent Capacitance
727
From the study of resistive circuits, it is understood that employing a series-parallel combination serves as an effective strategy for simplifying circuits. Capacitors can be arranged within a circuit in one of two ways: a series configuration or a parallel configuration. The way these capacitors are connected to a battery will influence both the potential drop across each individual capacitor and the size of the charge that each capacitor can store. This is determined by the specific type of...
727
01:18Thévenin Equivalent Circuits
701
The household power distribution system, encompassing distribution lines and transformers, serves as the primary network. Electrical appliances within a household can be represented as load impedance. To simplify this intricate distribution system, Thévenin's theorem can be applied to create a Thévenin equivalent circuit. If an AC circuit is partitioned into two parts (circuit A and circuit B), connected by a single pair of terminals as shown in Figure 1.
701
01:18Principle of Equivalence
2.6K
According to Albert Einstein (1897-1955), free-falling and feeling weightless are intrinsically linked. If a person were in free-fall under gravity, for example, diving towards the Earth from an airplane, they would feel completely weightless. Similarly, a person descending in a lift may feel partially weightless. Broadly speaking, it is assumed that an object in a uniform gravitational field and an object undergoing constant acceleration in the absence of gravity are under the same...
2.6K
01:28Equivalent Couples
695
In mechanical engineering, the concept of equivalent couples plays a crucial role in understanding and analyzing various mechanical systems.
Two couples are considered to be equivalent if they produce the same rotational effect on a rigid body. In other words, the two couples have the same magnitude and act in the same direction, causing the same angular displacement or acceleration in the body.
For instance, consider two couples lying in the plane of the page, with one having a pair of equal...
Two couples are considered to be equivalent if they produce the same rotational effect on a rigid body. In other words, the two couples have the same magnitude and act in the same direction, causing the same angular displacement or acceleration in the body.
For instance, consider two couples lying in the plane of the page, with one having a pair of equal...
695