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Vitamin D in children with growth hormone deficiency due to pituitary stalk interruption syndrome

Cécile Delecroix1, Raja Brauner2, Jean-Claude Souberbielle3

  • 1Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, Paris, France.

BMC Pediatrics
|January 26, 2018
PubMed

Insights

This study found that vitamin D levels in children with growth hormone (GH) deficiency due to pituitary stalk interruption syndrome (PSIS) are similar to healthy children. A positive correlation exists between GH peak and vitamin D metabolites, suggesting an interplay between the GH/IGF1 axis and vitamin D.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Biochemistry
  • Endocrine Disorders

Background:

  • Emerging evidence links vitamin D status with growth hormone (GH) and insulin-like growth factor 1 (IGF1) levels.
  • Pituitary stalk interruption syndrome (PSIS) is a cause of GH deficiency in children.

Purpose of the Study:

  • To evaluate vitamin D status in children with PSIS.
  • To explore the relationship between 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)2D) serum levels and patient characteristics in this cohort.

Main Methods:

  • A retrospective single-center study analyzed 25OHD and 1,25(OH)2D serum concentrations.
  • Data were collected from 50 children diagnosed with PSIS before initiating treatment.

Main Results:

  • Mean 25OHD was 33.2 ± 18.0 ng/mL and mean 1,25(OH)2D was 74.5 ± 40.7 ng/L.
  • 25OHD levels were higher in boys and during sunny seasons.
  • Significant positive correlations were found between GH peak and 1,25(OH)2D levels (p=0.015) and the 1,25(OH)2D/25OHD ratio (p<0.05).

Conclusions:

  • Vitamin D status in children with PSIS is comparable to healthy populations.
  • Despite impaired GH secretion and low IGF1, a significant interplay between the GH/IGF1 axis and vitamin D system persists in children with PSIS.
Abstract

Keywords:
1,25(OH)2D1,25-dihydroxyvitamin D25-hydroxyvitamin D25OHDGrowth hormoneGrowth hormone deficiencyInsulin-like growth factor 1Pituitary stalk interruption syndromeVitamin D

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