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Updated: Feb 15, 2026

Flavonoid Content During the Growth and Floral Development of Calendula officinalis L.
Published on: June 27, 2025
[Action of Calendula officinalis essence on bone preservation after the extraction]
Laura K Uribe-Fentanes1, Fernando Soriano-Padilla2, Jorge Raúl Pérez-Frutos3
1Servicio de Cirugía Oral y Maxilofacial, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, México.
Background:
Calendula officinalis is a phytodrug used as analgesic, antiseptic and wound-healing agent due to its collagenogenic effect, which is why it is a convenient and affordable treatment that promotes alveolar bone preservation after tooth extraction in vivo. The aim of this study was to use Calendula officinalis during and after tooth extraction to determine its ability to preserve bone after this procedure.
Methods:
We established two groups matched by age, gender and position of the third molar. We used with patients on the experimental group Calendula officinalis diluted 10% as an irrigant during surgical extraction of third molars. We performed the conventional way with the control group irrigating with saline solution. Subsequently, both groups continued to make mouthwash for a week with the irrigating agent. Every week for a month, each patient underwent periapical radiography, out of which we took measurements of alveolar ridges and depth of alveolar bone, which were compared.
Conclusions:
There is statistically significant evidence to state that Calendula officinalis favorably affects bone preservation after extraction.
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