Related Experiment Video

Updated: Feb 15, 2026

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.1K

Target home morning SBP be below 125 mmHg in type 2 diabetes patients

Kazuo Eguchi1, Satoshi Hoshide, Kazuomi Kario

  • 1Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

Journal of Hypertension
|January 26, 2018
PubMed

Insights

For patients with type 2 diabetes, a home morning systolic blood pressure (SBP) of 125 mmHg is a key indicator for cardiovascular risk. This cutoff value helps predict adverse cardiovascular outcomes more accurately in this population.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Self-monitoring of home blood pressure (BP) in type 2 diabetes patients is not well-established for cardiovascular risk stratification.
  • Previous studies have not clearly defined optimal home BP monitoring thresholds for this population.

Purpose of the Study:

  • To test the hypothesis that a home morning systolic blood pressure (SBP) cutoff of 125 mmHg is appropriate for stratifying cardiovascular risk in patients with type 2 diabetes.
  • To compare the predictive value of home morning SBP cutoffs of 135 mmHg and 125 mmHg for cardiovascular events.

Main Methods:

  • A cohort of 4308 individuals (1057 with type 2 diabetes, 3251 without) underwent clinic and home BP monitoring.
  • Multivariable Cox regression analyses were used to assess incident cardiovascular events (stroke, myocardial infarction, sudden death, acute aortic dissection), adjusting for multiple risk factors.
  • Kaplan-Meier analysis and log-rank tests were employed to evaluate the association between home morning SBP levels and cardiovascular events.

Main Results:

  • Home morning SBP of at least 135 mmHg was significantly associated with cardiovascular events in both diabetes and non-diabetes groups.
  • Home morning SBP of at least 125 mmHg was significantly associated with cardiovascular events in the type 2 diabetes group (P=0.012) but not in the non-diabetes group.
  • In multivariable analysis, home morning SBP ≥ 125 mmHg independently predicted cardiovascular events in type 2 diabetes patients (HR 4.35, P=0.045).

Conclusions:

  • The 125 mmHg cutoff for home morning systolic blood pressure is appropriate for predicting combined cardiovascular outcomes in patients with type 2 diabetes.
  • This finding aids in refining cardiovascular risk assessment and management strategies for individuals with type 2 diabetes.
Abstract

More Related Videos

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

3.1K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.7K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
511
Types of Hormones02:13

Types of Hormones

Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
84.6K