Related Experiment Videos
Prevalence of left-sided obstructive lesions in patients with atrioventricular canal without Down's syndrome
Insights
Patients with Down's syndrome rarely have left-sided obstructive lesions when diagnosed with atrioventricular canal. This contrasts with patients without Down's syndrome, who show a higher incidence of these cardiac defects.
Area of Science:
- Cardiology
- Genetics
- Pediatric Medicine
Background:
- Atrioventricular canal is a congenital heart defect.
- Left-sided obstructive lesions can occur with atrioventricular canal.
- Down's syndrome is associated with congenital heart defects.
Purpose of the Study:
- To investigate the association between left-sided obstructive lesions and Down's syndrome in patients with atrioventricular canal.
- To determine the prevalence of left-sided obstructive lesions in atrioventricular canal patients with and without Down's syndrome.
Main Methods:
- A study of 90 consecutive patients diagnosed with atrioventricular canal.
- Patients were categorized into three groups based on the presence and type of left-sided obstructive lesions.
- Prevalence of Down's syndrome was assessed in each group.
Main Results:
- Of 90 patients with atrioventricular canal, 47 had Down's syndrome.
- Only one patient (2.1%) with Down's syndrome had a left-sided obstructive lesion.
- In contrast, 13 out of 43 patients (30.2%) without Down's syndrome had left-sided obstructive lesions, predominantly at the inlet level.
Conclusions:
- Down's syndrome appears to have a protective association against left-sided obstructive lesions in patients with atrioventricular canal.
- Left-sided obstructive lesions in atrioventricular canal are more common in patients without Down's syndrome.
- Right ventricular dominance may contribute to inlet obstructive lesions in this population.
Abstract:
Ninety consecutive patients with atrioventricular canal were studied to identify the association between left-sided obstructive lesions and Down's syndrome. Three groups were recognized: Group I, 76 patients with atrioventricular canal and no left-sided obstructions; Group II, nine patients with atrioventricular canal and left-sided inlet obstructions; Group III, five patients with atrioventricular canal and left-sided outlet obstructions. Of the 90 patients studied, 47 had Down's syndrome and only one of these had a left-sided obstructive lesion. Of 43 without Down's syndrome, 13 or 30% had left-sided obstructive lesions with predominating lesions at the inlet level caused by right ventricular dominance.