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Related Experiment Video

Updated: Feb 15, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Current developments in phototherapy for psoriasis.

Akimichi Morita¹

¹Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

The Journal of Dermatology

|January 26, 2018

Summary

This summary is machine-generated.

Phototherapy using ultraviolet (UV) light, including narrowband UV-B (NB-UVB), treats psoriasis by inducing immune suppression and apoptosis. It effectively depletes pathogenic T cells and enhances regulatory T cells for improved skin health.

Keywords:

apoptosis excimer light immune suppression narrowband ultraviolet B regulatory T cells

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Published on: April 23, 2019

Area of Science:

Immunology
Dermatology
Photomedicine

Background:

Phototherapy leverages ultraviolet (UV) wavelengths to modulate immune functions.
Narrowband UV-B (NB-UVB) and bath-psoralen UV-A (bath-PUVA) are established psoriasis treatments.
UV phototherapy exhibits dual mechanisms: apoptosis induction and immune suppression.

Purpose of the Study:

To review the immunoregulatory effects of UV phototherapy in psoriasis.
To highlight advancements in phototherapy technologies and protocols.
To discuss the role of UV light in T cell modulation for skin diseases.

Main Methods:

Review of existing literature on UV phototherapy for psoriasis.
Analysis of molecular mechanisms, including apoptosis and T cell regulation.
Examination of different UV wavelengths and delivery systems (e.g., 308-nm excimer light).

Main Results:

NB-UVB therapy induces apoptosis and depletes pathogenic T cells while increasing regulatory T cells.
308-nm excimer light precisely targets affected skin, enhancing regulatory T cell levels.
Phototherapy demonstrates efficacy in improving regulatory T cell function in psoriasis patients.

Conclusions:

UV phototherapy, particularly NB-UVB and excimer light, offers effective treatment options for psoriasis.
Advancements in phototherapy, including UV light-emitting diodes, provide new avenues for refractory skin conditions.
Understanding UV-induced immunomodulation is key to optimizing psoriasis treatment.