Related Experiment Video
Updated: Feb 15, 2026
08:05
Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
20.0K
Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery
Xiaoyu Bai1, Zixian Bao2, Shichao Bi1
1College of Marine Life Science, Ocean University of China, Qingdao, 266003, P. R. China.
Macromolecular Bioscience
|January 26, 2018
Summary
Novel N-succinyl hydroxybutyl chitosan (NSHBC) hydrogels demonstrate tunable thermo/pH sensitivity for effective drug delivery. These advanced hydrogels show promising potential for oral drug delivery applications due to their pH-triggered release capabilities.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Chitosan-based hydrogels are widely explored for drug delivery.
- Developing materials with controlled release properties is crucial for therapeutic efficacy.
- Thermo/pH-sensitive hydrogels offer advanced control over drug release kinetics.
Purpose of the Study:
- To synthesize and characterize novel N-succinyl hydroxybutyl chitosan (NSHBC) hydrogels.
- To evaluate the thermo/pH sensitivity of NSHBC hydrogels for drug delivery.
- To assess the drug loading and release profiles of NSHBC hydrogels using bovine serum albumin (BSA) as a model drug.
Main Methods:
- Synthesis of NSHBC hydrogels with varying succinyl substitution degrees.
- Rheological analysis to determine gelation temperatures.
- In vitro drug release studies using BSA in phosphate-buffered saline (PBS) at different pH values (3.0 and 7.4).
Main Results:
- NSHBC hydrogels exhibited a higher gelation temperature (3.8 °C increase) compared to HBC hydrogels.
- BSA was successfully loaded and released from NSHBC hydrogels.
- Significantly higher BSA release (93.7%) was observed at pH 7.4 compared to pH 3.0 (24.6%) over 24 hours.
- HBC hydrogels showed less pH-dependent BSA release (~70.0% at both pH 3.0 and 7.4).
Conclusions:
- NSHBC hydrogels possess excellent pH-sensitive drug release characteristics.
- The tunable properties make NSHBC hydrogels highly adaptable for soluble drugs.
- These novel hydrogels show significant promise for applications in oral drug delivery systems.
Related Concept Videos
01:16Drug Delivery: Overview
925
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
925
01:18Drug Delivery: Enteral Route
1.9K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.9K
01:29Drug Delivery: Parenteral Route
1.8K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.8K
01:18Transdermal Drug Delivery Systems
21
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
21
01:23Ophthalmic Drug Delivery Systems
21
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
21
01:21Intrauterine Drug Delivery Systems
17
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
17