Related Experiment Video

Updated: Feb 15, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
08:43

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice

Published on: January 31, 2020

7.4K

Glucose-6-phosphate dehydrogenase deficiency in internationally adopted children

Rachel Spring1, Hanna Schlaack1, Marilyn Rice1

  • 1International Adoption Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Pediatric Blood & Cancer
|January 26, 2018
PubMed

Insights

Screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency in internationally adopted children is recommended. Prevalence varies by origin, with higher rates in males, impacting malaria treatment and preventing G6PD-related health issues.

Area of Science:

  • Genetics
  • Pediatrics
  • Public Health

Background:

  • Conflicting guidelines exist regarding screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency in internationally adopted children.
  • G6PD deficiency is a common genetic disorder with implications for various medical treatments and health outcomes.

Purpose of the Study:

  • To determine the prevalence of G6PD deficiency in a large cohort of internationally adopted children.
  • To analyze variations in G6PD deficiency prevalence based on country or region of origin.
  • To inform clinical practice and public health recommendations for screening.

Main Methods:

  • Retrospective analysis of G6PD deficiency screening results.
  • Inclusion of 2,169 multi-ethnic, internationally adopted children.
  • Stratification of prevalence data by sex and geographic origin.

Main Results:

  • Overall prevalence of G6PD deficiency was 1.6% in the study population.
  • Prevalence was higher in males (2.2%) compared to females (1%).
  • Significant variation in prevalence was observed based on country/region of origin, ranging from 0% to 13% overall and 0% to 22% in males.

Conclusions:

  • G6PD deficiency screening should be strongly considered for internationally adopted children due to varying prevalence.
  • Diagnosis aids in malaria treatment and prevents morbidity/mortality associated with G6PD deficiency.
  • Origin-specific prevalence data can guide targeted screening strategies.

Keywords:
G6PDadoptionglucose-6-phosphate dehydrogenase deficiencyinternational adoptionscreening

More Related Videos

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools11:29

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Published on: June 20, 2020

9.9K
Author Spotlight: Plant Primary Organs Profiling Using 13C6-Glucose Labeling and LC-MS04:32

Author Spotlight: Plant Primary Organs Profiling Using 13C6-Glucose Labeling and LC-MS

Published on: March 22, 2024

1.3K

Related Concept Videos

Internal Energy02:00

Internal Energy

The total of all possible kinds of energy present in a substance is called the internal energy (U), sometimes symbolized as E. Suppose a system with initial internal energy, Uinitial, undergoes a change in energy (transfer of work or heat), and the final internal energy of the system is Ufinal. Change in internal energy equals the difference between Ufinal and Uinitial.
36.9K
Internal Energy01:29

Internal Energy

The internal energy of a thermodynamic system is the sum of the kinetic and potential energies of all the molecules or entities in the system. The kinetic energy of an individual molecule includes contributions due to its rotation and vibration, as well as its translational energy. The potential energy is associated only with the interactions between one molecule and the other molecules of the system. Neither the system's location nor its motion is of any consequence as far as the internal...
7.2K
Phosphate Buffer01:22

Phosphate Buffer

The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
5.4K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.8K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.5K
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
27.6K