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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Related Experiment Video

Updated: Feb 15, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Autoimmunity in uveitis.

Josianne C Ten Berge1, Marco W J Schreurs2, Paul L A van Daele2

  • 1Department of Ophthalmology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.

Acta Ophthalmologica
|January 26, 2018
PubMed
Summary

Autoimmune and auto-inflammatory diseases are linked to uveitis and scleritis. Autoimmune cases, comprising 5% of patients, showed no legal blindness after 5 years, indicating a favorable visual prognosis in these immune-mediated eye conditions.

Keywords:
autoimmune diseasesautoimmunityepidemiologyinflammationscleritisuveitis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Immune-mediated diseases are now classified into autoimmune and auto-inflammatory categories.
  • The prevalence of these specific conditions in uveitis and/or scleritis patients remains largely unknown.
  • Understanding this association is crucial for accurate diagnosis and treatment of ocular inflammatory diseases.

Purpose of the Study:

  • To investigate the presence and characteristics of systemic immune-mediated diseases in patients diagnosed with uveitis and/or scleritis.
  • To specifically analyze autoimmune disorders, detailing their clinical manifestations and impact on visual prognosis.
  • To contribute to the updated classification of immune-mediated diseases by examining their ocular manifestations.

Main Methods:

  • A retrospective analysis of 1327 patients with uveitis and/or scleritis treated between 2010 and 2016.
  • Classification of noninfectious uveitis and/or scleritis cases based on novel immune-mediated disease criteria.
  • Collection and analysis of clinical data, including visual acuity (VA), over a 5-year follow-up period for autoimmune uveitis patients.

Main Results:

  • Autoimmune uveitis was identified in 5% of patients, auto-inflammatory in 15%, and mixed in 14%.
  • Patients with autoimmune connective tissue diseases predominantly presented with scleritis (53%) and had no legal blindness after 5 years.
  • Uveitis associated with autoimmune neuro-ophthalmological diseases showed stable visual acuity over the follow-up period.

Conclusions:

  • Autoimmune uveitis and scleritis account for 5% of the studied cases.
  • The findings support the distinction between autoimmune uveitis and general noninfectious intraocular inflammation.
  • Autoimmune-related ocular inflammation, while significant, may have a manageable visual prognosis.