Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Determining optimal therapy--randomized trials in individual patients.

G Guyatt, D Sackett, D W Taylor

    The New England Journal of Medicine
    |April 3, 1986
    PubMed
    Summary

    This study introduces a novel single-patient clinical trial method for evaluating treatment efficacy. This approach minimizes bias and provides clear results for individual patient treatment, as demonstrated in a case of airflow limitation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Diagnostic and intervention value of implantable cardiac monitor in patients over 60 years of age with unexplained syncope].

    Zhonghua xin xue guan bing za zhi·2024
    Same author

    Breeding oat for resistance to the crown rust pathogen Puccinia coronata f. sp. avenae: achievements and prospects.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2022
    Same author

    Canadian Surgery Forum.

    Canadian journal of surgery. Journal canadien de chirurgie·2022
    Same author

    Efficacy and Safety of Nemolizumab for Treatment of Adult Atopic Dermatitis: A Meta-analysis of Randomized Clinical Trials.

    Journal of investigational allergology & clinical immunology·2021
    Same author

    An artificial intelligence algorithm that differentiates anterior ethmoidal artery location on sinus computed tomography scans.

    The Journal of laryngology and otology·2019
    Same author

    How to differentiate uterine leiomyosarcoma from leiomyoma with imaging.

    Diagnostic and interventional imaging·2019

    Area of Science:

    • Clinical Medicine
    • Medical Research Methodology

    Background:

    • Individual patient treatment is often experimental but susceptible to bias.
    • Traditional multi-patient trials are not feasible for all conditions and may not apply to individual patients.
    • A need exists for reliable efficacy assessment in individual patient care.

    Purpose of the Study:

    • To introduce and validate a novel double-blind, randomized trial design for single patients.
    • To demonstrate the utility of this method in assessing treatment efficacy for specific clinical disorders.
    • To establish a clinical service for implementing this single-patient trial approach.

    Main Methods:

    • Employed double-blind, randomized trials where a single patient receives paired active and placebo/alternative treatments.

    Related Experiment Videos

  • Treatment order was randomly allocated.
  • Efficacy was measured using appropriate treatment targets (signs, symptoms, laboratory tests).

    • Main Results:

    • The described trial successfully established treatment efficacy.
    • A dramatically beneficial modification of treatment was achieved for a patient with partially reversible airflow limitation.
    • The method proved effective in determining treatment outcomes for an individual.

    Conclusions:

    • Single-patient, double-blind randomized trials offer a viable solution to assess treatment efficacy when traditional methods are unsuitable.
    • This methodology can lead to significant treatment improvements for individual patients.
    • The established clinical service supports the broader adoption of this innovative trial design.