Iohexol in paediatric myelography. An open non-comparative trial

Area of Science:

• Neuroradiology
• Pediatric Imaging
• Contrast Media Research

Background:

• Myelography is a crucial diagnostic tool for pediatric spinal conditions.
• Evaluating the safety and efficacy of non-ionic contrast media in pediatric populations is essential.
• Iohexol is a non-ionic, low-osmolar contrast agent used in various imaging procedures.

Purpose of the Study:

• To assess the safety and tolerability of iohexol in pediatric myelography.
• To evaluate the diagnostic utility of iohexol across different iodine concentrations and dosages.
• To document any adverse reactions associated with iohexol administration in children.

Main Methods:

• 148 children (5 days to 16 years) underwent lumbar puncture myelography with iohexol.
• Iohexol concentrations ranged from 180 to 300 mgI/ml, with doses adjusted by body weight.
• Neurological examinations, vital sign monitoring, and electroencephalograms (EEGs) were performed pre- and post-procedure.

Main Results:

• No unexpected or severe adverse reactions were reported in any of the 148 patients.
• Minor, transient variations in pulse rate and blood pressure were noted but were not clinically significant.
• EEG showed minor, slow-wave abnormalities in 7 patients, with no epileptogenic activity observed.

Conclusions:

• Iohexol is a safe and well-tolerated contrast medium for pediatric myelography.
• The study supports the use of iohexol in pediatric neuroradiology for effective spinal imaging.
• Iohexol demonstrates a favorable safety profile, with no significant adverse events in this cohort.