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Updated: Feb 15, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Diabetes medications and cardiovascular disease: at long last progress
Beatrice C Lupsa1, Silvio E Inzucchi
1Section of Endocrinology, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.
Purpose Of Review:
Although intensive control of hyperglycemia has been proven to decrease the risk of microvascular complications in type 2 diabetes, it has had little apparent effect on reducing cardiovascular complications - the leading cause of mortality in this disease. We review the cardiovascular effects of various glucose-lowering medications, with a particular focus on the recent studies demonstrating clear benefits from members of several drug categories.
Recent Findings:
Recently, several randomized controlled studies have revealed significant improvements in cardiovascular outcomes from a thiazolidinedione, two sodium-glucose cotransporter 2 inhibitors and two glucagon-like peptide 1 receptor agonists.
Summary:
These data suggest that certain glucose lowering agents after metformin should be favored in type 2 diabetes mellitus patients when there is underlying cardiovascular disease.
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