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THROMBOCYTOPENIA AS A RISK FACTOR FOR RETINOPATHY OF PREMATURITY

Selim Sancak1, Handan H Toptan1, Tulin Gokmen Yildirim1

  • 1Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, TR.

Retina (Philadelphia, Pa.)
|January 26, 2018
PubMed

Insights

Thrombocytopenia, a low platelet count, is significantly linked to severe retinopathy of prematurity (ROP) requiring intervention. This finding highlights the importance of monitoring platelet levels in premature infants at risk for ROP.

Area of Science:

  • Neonatalogy
  • Ophthalmology
  • Hematology

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of vision impairment in premature infants.
  • Thrombocytopenia is a common complication in preterm neonates.
  • The relationship between thrombocytopenia and the severity of ROP is not fully understood.

Purpose of the Study:

  • To investigate the association between thrombocytopenia and the development of severe retinopathy of prematurity (ROP) requiring intervention.

Main Methods:

  • A case-control study involving 81 premature infants with ROP was conducted retrospectively.
  • Infants were categorized into two groups: cases (requiring intervention) and controls (no or Stage I ROP).
  • Thrombocytopenia was defined as a platelet count below 150,000/mm³.

Main Results:

  • Thrombocytopenia was significantly more prevalent in infants with severe ROP (71.6%) compared to controls (21%) (P < 0.001).
  • Logistic regression identified thrombocytopenia as a significant risk factor for severe ROP (RR: 6.69 [2.83-15.9]).
  • Bronchopulmonary dysplasia was also associated with severe ROP.

Conclusions:

  • A significant association exists between thrombocytopenia and severe, intervention-requiring retinopathy of prematurity (Type I ROP).
  • Monitoring platelet counts may be crucial for managing premature infants at risk for severe ROP.
Abstract

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