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Association of ambulatory blood pressure variability with coronary artery calcium

Bailey DeBarmore1, Feng-Chang Lin2,3, Laura A Tuttle4

  • 1Department of Epidemiology, Gillings School of Global, Public Health University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Journal of Clinical Hypertension (Greenwich, Conn.)
|January 26, 2018
PubMed

Insights

Blood pressure variability did not predict coronary artery calcium in individuals without diagnosed heart disease. This suggests 24-hour blood pressure monitoring may not be a useful predictor in low-risk populations.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Preventive Cardiology

Background:

  • Blood pressure (BP) variability is linked to atherosclerosis progression.
  • Predictive value of BP variability for cardiovascular outcomes in low-risk groups remains unclear.

Purpose of the Study:

  • To investigate the association between 24-hour BP variability and coronary artery calcium (CAC) in individuals without coronary artery disease.
  • To assess if BP variability predicts subclinical atherosclerosis in a low-risk cohort.

Main Methods:

  • The study included individuals with borderline high BP from the Masked Hypertension Study.
  • Ambulatory blood pressure monitoring (ABPM) was conducted twice, 8 days apart.
  • Coronary artery calcium (CAC) was measured using cardiac CT and quantified with the Agatston Score.

Main Results:

  • No significant difference in BP variability was observed between participants with and without CAC.
  • CAC was not associated with 24-hour ambulatory BP variability in this low cardiovascular risk group.

Conclusions:

  • In individuals without diagnosed coronary artery disease, 24-hour BP variability is not associated with the presence of coronary artery calcium.
  • These findings suggest BP variability may not be a reliable predictor of subclinical atherosclerosis in low-risk populations.

Keywords:
ambulatory blood pressureblood pressure monitoringblood pressure variabilitycoronary artery calcium

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