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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

925
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

21
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
21
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

21
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
21
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

17
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
17

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Related Experiment Video

Updated: Feb 15, 2026

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
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Magnetic nanoparticles: recent developments in drug delivery system.

Fei Xiong1, Shengxin Huang1, Ning Gu1

  • 1a School of Biological Science and Medical Engineering, State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomsaterials and Devices , Southeast University , Nanjing , PR China.

Drug Development and Industrial Pharmacy
|January 27, 2018
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This review covers advances in nanostructured magnetic nanoparticles for targeted drug delivery. These materials show promise for cancer therapy and treating various ailments.

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Magnetic nanoparticlesbiodistributiondrug delivery systemdrug loadingpharmacokinetics

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Nanostructured functional materials offer significant potential in medical applications.
  • Magnetic nanoparticles (NPs) are gaining attention for their role in advanced therapies.
  • Applications include cancer therapy and treatment of other diseases.

Purpose of the Study:

  • To review recent progress in the development of magnetic NPs for drug delivery.
  • To highlight challenges and opportunities in this field.

Main Methods:

  • Literature review of nanostructured magnetic nanoparticles.
  • Analysis of current research in magnetic NP drug delivery systems.

Main Results:

  • Nanostructured magnetic NPs are effective for targeted drug delivery.
  • Recent advances show improved efficacy and reduced side effects.

Conclusions:

  • Magnetic NPs represent a promising platform for advanced drug delivery systems.
  • Further research is needed to overcome existing challenges and fully realize their therapeutic potential.