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Relationship Between Visceral Infarction and Ischemic Stroke Subtype

Caitlin Finn1, Peter Hung1, Praneil Patel1

  • 1From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, New York, NY (C.F., P.H., H.K.); and Departments of Radiology (P.P., A.G.) and Neurology (A.G., H.K.), Weill Cornell Medical College, New York, NY.

Stroke
|January 27, 2018
PubMed

Insights

Cryptogenic strokes, often presumed embolic, were linked to visceral infarcts. This study found a higher prevalence of kidney and spleen infarcts in cardioembolic and cryptogenic stroke patients compared to others.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Most cryptogenic strokes are presumed to have an embolic origin.
  • Visceral infarcts, such as renal or splenic, are typically embolic in nature.

Purpose of the Study:

  • To investigate the association between cryptogenic strokes and visceral infarcts.
  • To determine if cryptogenic strokes share embolic characteristics with visceral infarcts.

Main Methods:

  • Patients from the Cornell Acute Stroke Academic Registry (CAESAR) with abdominal CT scans were analyzed.
  • Stroke subtypes were classified, and the presence of renal or splenic infarcts was assessed.
  • Statistical analyses, including Fisher exact test and logistic regression, were employed.

Main Results:

  • Among 227 patients, 59 had visceral infarcts (35 renal, 27 splenic).
  • Visceral infarction prevalence was significantly higher in cardioembolic (34.2%) and cryptogenic (23.9%) strokes compared to noncardioembolic strokes (12.5%).
  • Logistic regression confirmed significant associations between visceral infarcts and both cardioembolic (OR 3.5) and cryptogenic strokes (OR 3.3).

Conclusions:

  • The prevalence of visceral infarction varies significantly across ischemic stroke subtypes.
  • Cardioembolic and cryptogenic strokes show a higher association with visceral infarcts, suggesting a potential shared embolic etiology.
Abstract

Keywords:
atherosclerosisembolismsplenic infarctionstroketomography

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