Patient Susceptibility to Candidiasis-A Potential for Adjunctive Immunotherapy

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Linda Davidson1, Mihai G Netea2, Bart Jan Kullberg3

  • 1Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands. Linda.Davidson@radboudumc.nl.

Journal of Fungi (Basel, Switzerland)
|January 27, 2018
PubMed

Insights

Candida fungi commonly colonize healthy individuals. Genetic factors and immune defects increase susceptibility to invasive candidiasis, necessitating research into adjunctive immunotherapies.

Area of Science:

  • Immunology
  • Medical Mycology
  • Genetics

Background:

  • Candida species are commensal fungi found on human skin and mucosae.
  • Host immune defenses normally prevent Candida invasion.
  • Impaired immunity, barrier dysfunction, or microbiome imbalance can lead to candidiasis.

Purpose of the Study:

  • To review patient susceptibility to mucocutaneous and invasive candidiasis.
  • To explore the potential for adjunctive immunotherapy in managing Candida infections.
  • To highlight the role of genetic predisposition in Candida susceptibility.

Main Methods:

  • This is a review article.
  • It synthesizes existing literature on Candida infections and host immunity.
  • It discusses genetic and non-genetic factors influencing susceptibility.

Main Results:

  • Susceptibility to candidiasis is often multifactorial, involving genetic polymorphisms and environmental factors.
  • Understanding immune responses is crucial for developing new treatments.
  • Identifying genetic predispositions may guide prophylactic strategies.

Conclusions:

  • Adjunctive immunotherapy holds promise for treating invasive candidiasis.
  • Further research into host-pathogen interactions and genetic susceptibility is warranted.
  • Personalized treatment approaches may benefit high-risk patients.
Keywords:
candidemiachronic mucocutaneous candidiasis (CMC)genetic predispositionhyper IgE syndromeimmune defenseimmunotherapyinvasive candidiasismucocutaneous candidiasispatient susceptibility

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