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A Study of Microalbuminuria (MAU) and Advanced Glycation End Products (AGEs) Levels in Diabetic and Hypertensive

S Gawandi1, S Gangawane2, A Chakrabarti2

  • 11Radiation Medicine Centre, Bhabha Atomic Research Centre (BARC), Mumbai, India.

Indian Journal of Clinical Biochemistry : IJCB
|January 27, 2018
PubMed

Insights

Early detection of kidney damage in diabetes mellitus (DM), hypertension (HTN), and pregnancy-induced hypertension (PIH) is crucial. Screening for microalbuminuria (MAU) and advanced glycation end products (AGEs) can help identify at-risk patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Clinical Chemistry

Background:

  • Non-communicable diseases like diabetes mellitus (DM) and hypertension (HTN) are globally prevalent and can lead to nephropathy.
  • Microalbuminuria (MAU) is an early indicator of kidney damage, while advanced glycation end products (AGEs) are important prognostic factors in diabetic nephropathy.

Purpose of the Study:

  • To evaluate microalbuminuria (MAU) and advanced glycation end products (AGEs) as early biomarkers for nephropathy in patients with DM, HTN, and pregnancy-induced hypertension (PIH).

Main Methods:

  • Serum levels of MAU and Nε-Carboxymethyllysine (CML) were measured using in-house RIA kits.
  • Total AGEs in serum were quantified using ELISA.
  • Levels were compared between patient groups (DM, HTN, PIH) and healthy controls.

Main Results:

  • MAU, CML, and AGE-BSA levels were significantly elevated (p < 0.001) in DM, HTN, and PIH subjects compared to controls.
  • Increased serum CML and AGEs suggest ongoing glycemic damage and susceptibility to renal complications.

Conclusions:

  • Elevated MAU and AGEs (including CML) serve as valuable early indicators of nephropathy risk in DM, HTN, and PIH.
  • These biomarkers facilitate early clinical diagnosis and intervention to prevent renal complications.
Keywords:
Advanced glycation end productsMicroalbuminuriaNephropathy radioimmunoassay

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