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[Indices of T-lymphocytes and their subpopulations in children with influenza]
Insights
Influenza in children significantly reduces T lymphocytes, particularly in severe cases like pneumonia. Low T lymphocyte levels indicate a high-risk group needing immunocorrective therapy.
Area of Science:
- Pediatrics
- Immunology
- Infectious Diseases
Background:
- Influenza is a common respiratory illness in children.
- Complications such as croup, pneumonia, and obstructive syndrome can arise.
- The role of T lymphocytes in pediatric influenza and its complications requires further elucidation.
Purpose of the Study:
- To investigate T lymphocyte and subpopulation levels in children with influenza.
- To assess the impact of influenza complications and mixed infections on T lymphocytes.
- To identify children at risk and suggest therapeutic strategies.
Main Methods:
- Studied 150 children (2 months to 5 years) with influenza and complications.
- Included 47 children with mixed influenza and other viral infections.
- Utilized a control group of 22 healthy children.
- Analyzed T lymphocyte and E-theophylline-sensitive T lymphocyte levels.
Main Results:
- A decrease in T lymphocytes and subpopulations was observed during acute influenza.
- The most significant reduction occurred in children with pneumonia and obstructive syndrome.
- Mixed infections, particularly influenza with adenovirus, showed more pronounced T lymphocyte inhibition.
- Lowered T lymphocyte levels correlated with increased risk.
Conclusions:
- Influenza significantly impacts pediatric T lymphocyte immunity.
- Pneumonia and obstructive syndrome exacerbate T lymphocyte suppression.
- Children with reduced T lymphocytes post-influenza are a risk group.
- Immunocorrective therapy may be beneficial for these children.
Abstract:
The results of the study of T lymphocytes and their subpopulations in 150 children ranging in age from 2 months to 5 years suffering from influenza complicated with croup, pneumonia, and obstructive syndrome are presented. In 47 children, mixed infection: influenza with concomitant adenovirus infection or respiratory-syncytial infection was observed. The control group consisted of 22 normal children. In the acute period of influenza the number of T lymphocytes and their subpopulations was found to decrease. The greatest decrease in the levels of T lymphocytes and especially of E-theophylline-sensitive ones was observed in cases complicated with pneumonia and obstructive syndrome. In mixed infections, inhibition of E-RFC and their subpopulations was more marked in influenza and adenovirus disease. The data obtained by catamnestic observations of children with lowered levels of T lymphocytes suggest that such children should be referred to a risk group and apparently require immunocorrective therapy.