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Epidemiology of Chronic Hepatitis C Infections at a Tertiary Care Centre in Oman
Said A Al-Busafi1, Halima Al-Shuaili2, Heba Omar3
1Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.
Insights
This study describes chronic hepatitis C (CHC) in Oman, finding high rates of cirrhosis and liver cancer. Early screening and prevention policies are recommended to reduce the disease burden.
Area of Science:
- Hepatology
- Epidemiology
- Public Health
Background:
- Chronic hepatitis C (CHC) is a significant global cause of liver cirrhosis and hepatocellular carcinoma (HCC).
- Limited epidemiological data exists for CHC in Oman, necessitating local characterization.
- Understanding CHC epidemiology is crucial for targeted public health interventions.
Purpose of the Study:
- To delineate the clinicopathological features of CHC patients in Oman.
- To analyze the outcomes of CHC infection at a tertiary care hospital.
- To provide baseline data for national hepatitis C control strategies.
Main Methods:
- Retrospective, descriptive, hospital-based study.
- Inclusion of 603 CHC patients at Sultan Qaboos University Hospital (2010-2015).
- Analysis of demographic, clinical, laboratory, and radiological data.
Main Results:
- The cohort comprised 65.8% males with a mean age of 44.8 years.
- Key risk factors included intravenous drug abuse (23.9%) and blood transfusions (20.7%).
- Hepatitis C virus genotypes 1 and 3 were most common; 33.0% had cirrhosis, and 23.1% had HCC at presentation.
Conclusions:
- Significant prevalence of cirrhosis and HCC among CHC patients in Oman.
- Low rates of liver transplantation for eligible patients.
- Urgent need for national policies on CHC prevention and early screening.
Objectives:
Chronic hepatitis C (CHC) is a leading cause of liver cirrhosis and hepatocellular carcinoma (HCC) worldwide. However, there is a lack of data regarding the epidemiology of CHC in Oman. This study aimed to describe the clinicopathological characteristics and outcomes of CHC-infected patients at a tertiary care hospital in Oman.
Methods:
This retrospective descriptive hospital-based study included all CHC-infected patients who presented to the Sultan Qaboos University Hospital (SQUH) in Muscat, Oman, between January 2010 and December 2015. The baseline demographic, clinical, laboratory and radiological data of the patients were analysed.
Results:
A total of 603 CHC-infected patients were identified during the study period; of these, 65.8% were male and the mean age was 44.8 ± 16.5 years. The main risk factors associated with CHC infection were intravenous drug abuse (23.9%) and a history of blood transfusions (20.7%). The most prevalent virus genotypes were 1 and 3 (44.0% and 35.1%, respectively). Upon initial presentation, 33.0% of the cohort had liver cirrhosis; of these, 48.7% had decompensated cirrhosis and 23.1% had HCCs. Liver transplantation was only performed for 7.5% of the cirrhosis patients, mostly as a curative treatment for HCC.
Conclusion:
The implementation of national policies to prevent hepatitis C transmission and encourage the early screening of at-risk patients is recommended to reduce the burden and consequences of this disease in Oman.
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